Maria Filopoulou was born in Athens in 1964. She studied painting at the École Nationale Supérieure des Beaux-Arts in Paris (1984–1988) under Leonardo Cremonini and completed postgraduate studies there in 1988–1989 with a French government scholarship, specializing in lithography with Abraham Hadad.

Her work is held in major public and private collections, including the National Gallery in Athens, the Greek Parliament, the Bank of Greece, the Goulandris Museum, the Sotiris Felios Collection, among others in Greece and internationally.

She has presented more than twenty solo exhibitions in cities including Athens (represented by Zoumboulakis Galleries), Thessaloniki, London, New York, Paris, and Istanbul, and has participated in numerous group exhibitions worldwide.